Chemical Structure : Dirlotapide
CAS No.: 481658-94-0
Catalog No.: PC-24765Not For Human Use, Lab Use Only.
Dirlotapide (CP742033) is a potent inhibito rof microsomal triglyceride transfer protein (MTP), inhibits Apo B secretion from human HepG2 cells and in canine hepatocytes with IC50 of 1.5 nM and 2.9 nM respectively.
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Dirlotapide (CP742033) is a potent inhibito rof microsomal triglyceride transfer protein (MTP), inhibits Apo B secretion from human HepG2 cells and in canine hepatocytes with IC50 of 1.5 nM and 2.9 nM respectively.
Dirlotapide showed excellent efficacy when tested in a canine food intake model.
M.Wt | 674.72 | |
Formula | C40H33F3N4O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(S)-N-[2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[4'-(trifluoromethyl)-2-biphenylylcarboxamido]indole-2-carboxamide |
1. Li J, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1996-9.
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