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Dirlotapide

Chemical Structure : Dirlotapide

CAS No.: 481658-94-0

Dirlotapide (CP742033)

Catalog No.: PC-24765Not For Human Use, Lab Use Only.

Dirlotapide (CP742033) is a potent inhibito rof microsomal triglyceride transfer protein (MTP), inhibits Apo B secretion from human HepG2 cells and in canine hepatocytes with IC50 of 1.5 nM and 2.9 nM respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dirlotapide (CP742033) is a potent inhibito rof microsomal triglyceride transfer protein (MTP), inhibits Apo B secretion from human HepG2 cells and in canine hepatocytes with IC50 of 1.5 nM and 2.9 nM respectively.
Dirlotapide showed excellent efficacy when tested in a canine food intake model.

Physicochemical Properties

M.Wt 674.72
Formula C40H33F3N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-[2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[4'-(trifluoromethyl)-2-biphenylylcarboxamido]indole-2-carboxamide

References

1. Li J, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1996-9.

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