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Disitertide

Chemical Structure : Disitertide

CAS No.: 272105-42-7

Disitertide (P144, P144 Peptide)

Catalog No.: PC-47500Not For Human Use, Lab Use Only.

Disitertide (P144) is a TGF-β1 antagonist peptide, induces apoptosis in GBM cell lines and reduces SMAD2 phosphorylation with downregulation of SKI and an upregulation of SMAD7 at both transcriptional and translational levels; active in vivo.

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Biological Activity

Disitertide (P144) is a TGF-β1 antagonist peptide, induces apoptosis in GBM cell lines and reduces SMAD2 phosphorylation with downregulation of SKI and an upregulation of SMAD7 at both transcriptional and translational levels; active in vivo.

Physicochemical Properties

M.Wt 1580.824
Formula C68H109N17O22S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO

Chemical Name/SMILES

L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-

References

1. Gallo-Oller G, et al. Cancer Lett. 2016 Oct 10;381(1):67-75.

2. Baltanas A, et al. Antioxid Redox Signal. 2013 Nov 10;19(14):1607-18.

3. Diaz-Valdes N, et al. Cancer Res. 2011 Feb 1;71(3):812-21.

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