Chemical Structure : DksA inhibitor Compound 916
CAS No.:
634169-82-7
DksA inhibitor Compound 916
Catalog No.: PC-28359Not For Human Use, Lab Use Only.
DksA inhibitor Compound 916 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 928 nM, has MIC50 of 32 ug/mL against nontyphoidal S. enterica serovar Typhimurium strain 14028s and E. coli strain W3110.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DksA inhibitor Compound 916 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 928 nM, has MIC50 of 32 ug/mL against nontyphoidal S. enterica serovar Typhimurium strain 14028s and E. coli strain W3110.
Compound 916 (0.1 uM) completely inhibits DksA-dependent activation of hisG in vitro transcription.
Compound 916 inhibits virulence gene transcription of intracellular Salmonella.
Compound 916 inhibits transcription of DksA-dependent housekeeping genes and the sifA virulence gene.
DksA is an allosteric regulator of RNA polymerase in Gram-negative bacteria.
Physicochemical Properties
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M.Wt
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248.24
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Formula
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C11H12N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3,4-dimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamide
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References
1. Kim JS, et al. Sci Adv. 2026 Mar 20;12(12):eaea6832.
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