Chemical Structure : DnaK inhibitor M7
CAS No.:
DnaK inhibitor M7
Catalog No.: PC-28084Not For Human Use, Lab Use Only.
DnaK inhibitor M7 is a small molecule inhibitor of bacterial Hsp70 protein DnaK ATPase, inhibits DnaK-mediated ATP hydrolysis with IC50 of 8.4 uM, likely engages the substrate-binding pocket of DnaK, induces accumulation of σ-32 without affecting protein translation, effectively inhibits the growth of E. coli AS19 and some Gram-positive bacteria, including Staphylococcus aureus and Bacillus cereus.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DnaK inhibitor M7 is a small molecule inhibitor of bacterial Hsp70 protein DnaK ATPase, inhibits DnaK-mediated ATP hydrolysis with IC50 of 8.4 uM, likely engages the substrate-binding pocket of DnaK, induces accumulation of σ-32 without affecting protein translation, effectively inhibits the growth of E. coli AS19 and some Gram-positive bacteria, including Staphylococcus aureus and Bacillus cereus.
Physicochemical Properties
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M.Wt
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919.05
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Formula
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C46H62N8O12
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5,5'-((5,5'-(((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(azanediyl))bis(6-isobutoxypicolinoyl))bis(azanediyl))bis(6-(sec-butoxy)picolinic acid)
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References
1. Upadhyay T, et al. Chembiochem. 2026 Sep 14;27(17):e70518.
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