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Chemical Structure : Dofequidar fumarate
CAS No.: 153653-30-6
Catalog No.: PC-45137Not For Human Use, Lab Use Only.
Dofequidar fumarate (MS-209) is an orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
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Dofequidar fumarate (MS-209) is an orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
Dofequidar completely reverses resistance against vincristine in vitro in multidrug-resistant variants of mouse leukemia P388 cells and human leukemia K562 cells at 1-10 uM.
Dofequidar greatly reduces the SP-derived tumor growth in vivo combined with CPT-11.
| M.Wt | 597.6576 | |
| Formula | C34H35N3O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 56 mg/mL |
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| Chemical Name/SMILES |
Ethanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-, (2E)-2-butenedioate (1:1) |
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1. Nakanishi O, et al. Oncol Res. 1997;9(2):61-9.
2. Sato W, et al. Cancer Chemother Pharmacol. 1995;35(4):271-7.
3. Katayama R, et al. Cancer Sci. 2009 Nov;100(11):2060-8.
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