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Dofequidar fumarate

Chemical Structure : Dofequidar fumarate

CAS No.: 153653-30-6

Dofequidar fumarate (MS-209, MS209)

Catalog No.: PC-45137Not For Human Use, Lab Use Only.

Dofequidar fumarate (MS-209) is an orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dofequidar fumarate (MS-209) is an orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
Dofequidar completely reverses resistance against vincristine in vitro in multidrug-resistant variants of mouse leukemia P388 cells and human leukemia K562 cells at 1-10 uM.
Dofequidar greatly reduces the SP-derived tumor growth in vivo combined with CPT-11.

Physicochemical Properties

M.Wt 597.6576
Formula C34H35N3O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 56 mg/mL

Chemical Name/SMILES

Ethanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-, (2E)-2-butenedioate (1:1)

References

1. Nakanishi O, et al. Oncol Res. 1997;9(2):61-9.

2. Sato W, et al. Cancer Chemother Pharmacol. 1995;35(4):271-7.

3. Katayama R, et al. Cancer Sci. 2009 Nov;100(11):2060-8.

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