Dolutegravir |CAS:1051375-16-6 Probechem Biochemicals

Chemical Structure : Dolutegravir

CAS No.: 1051375-16-6

Dolutegravir (GSK1349572;GSK-1349572;GSK 1349572)

Catalog No.: PC-43417Not For Human Use, Lab Use Only.

Dolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.

Packing	Price	Stock
5 mg	$98	In stock
25 mg	$278	In stock
100 mg	$748	In stock
500 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Dolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM; inhibits HIV-1 replication in PBMCs, MT-4 cells and in the PHIV assay with EC50 of 0.51, 0.71 and 2.2 nM, respectively; demonstrates activity against site-directed molecular clones containing the raltegravir-resistant signature mutations Y143R, Q148K, N155H, and G140S/Q148H; exhibits excellent anti-HIV activity in combination with representative approved antiretroviral agents in vivo.

HIV Infection

Approved

Physicochemical Properties

M.Wt	419.3788
Formula	C20H19F2N3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 10 mg/mL
Chemical Name/SMILES	2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-

References

1. Kobayashi M, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21.

2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.

3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.

4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.

Dolutegravir (GSK1349572;GSK-1349572;GSK 1349572)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.