Dolutegravir sodium |CAS:1051375-19-9 Probechem Biochemicals

Chemical Structure : Dolutegravir sodium

CAS No.: 1051375-19-9

Dolutegravir sodium (GSK-1349572A)

Catalog No.: PC-43418Not For Human Use, Lab Use Only.

Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.

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Biological Activity

Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM; inhibits HIV-1 replication in PBMCs, MT-4 cells and in the PHIV assay with EC50 of 0.51, 0.71 and 2.2 nM, respectively; demonstrates activity against site-directed molecular clones containing the raltegravir-resistant signature mutations Y143R, Q148K, N155H, and G140S/Q148H; exhibits excellent anti-HIV activity in combination with representative approved antiretroviral agents in vivo.

HIV Infection

Approved

Physicochemical Properties

M.Wt	441.3606
Formula	C20H18F2N3NaO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 4.4 mg/mL; DMSO: < 12.6 mg/mL
Chemical Name/SMILES	2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, sodium salt (1:1), (4R,12aS)-

References

1. Kobayashi M, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21.

2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.

3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.

4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.

Dolutegravir sodium (GSK-1349572A)

Biological Activity

Physicochemical Properties

References

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