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Chemical Structure : Donecopride
Catalog No.: PC-23390Not For Human Use, Lab Use Only.
Donecopride (MR31147) is a potent, dual serotonin subtype 4 receptor (5-HT4) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 8.5 nM (5-HT4eR) and IC50 of 16 nM (hAChE).
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Donecopride (MR31147) is a potent, dual serotonin subtype 4 receptor (5-HT4) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 8.5 nM (5-HT4eR) and IC50 of 16 nM (hAChE).
Donecopride is a potent, selective, and partial (h)5-HT4eR agonist.
Donecopride promotes sAPPα secretion in an in vitro cellular model to a similar degree as RS67333.
Donecopride exhibits a significant procognitive effect during the object recognition task.
| M.Wt | 392.97 | |
| Formula | C22H33ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rochais C, et al. Eur J Med Chem. 2024 Oct 18;280:116975.
2. Rochais C, et al. Br J Pharmacol. 2020 May;177(9):1988-2005.
3. Rochais C, et al. J Med Chem. 2015 Apr 9;58(7):3172-87.
4. Lecoutey C, et al. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3825-30.
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