Chemical Structure : Donecopride
CAS No.:
1624996-89-9
Donecopride
(MR31147)
Catalog No.: PC-23390Not For Human Use, Lab Use Only.
Donecopride (MR31147) is a potent, dual serotonin subtype 4 receptor (5-HT4) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 8.5 nM (5-HT4eR) and IC50 of 16 nM (hAChE).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Donecopride (MR31147) is a potent, dual serotonin subtype 4 receptor (5-HT4) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 8.5 nM (5-HT4eR) and IC50 of 16 nM (hAChE).
Donecopride is a potent, selective, and partial (h)5-HT4eR agonist.
Donecopride promotes sAPPα secretion in an in vitro cellular model to a similar degree as RS67333.
Donecopride exhibits a significant procognitive effect during the object recognition task.
Physicochemical Properties
|
M.Wt
|
392.97
|
|
Formula
|
C22H33ClN2O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
|
References
1. Rochais C, et al. Eur J Med Chem. 2024 Oct 18;280:116975.
2. Rochais C, et al. Br J Pharmacol. 2020 May;177(9):1988-2005.
3. Rochais C, et al. J Med Chem. 2015 Apr 9;58(7):3172-87.
4. Lecoutey C, et al. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3825-30.
Contact Us
sales@probechem.com
