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Donepezil hydrochloride

Chemical Structure : Donepezil hydrochloride

CAS No.: 120011-70-3

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Donepezil hydrochloride (E2020)

Catalog No.: PC-27408Not For Human Use, Lab Use Only.

Donepezil hydrochloride (E2020) is a potent, specific acetylcholinesterase (AChE) inhibitor with IC50 of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.

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100 mg $58 In stock
250 mg $88 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Donepezil hydrochloride (E2020) is a potent, specific acetylcholinesterase (AChE) inhibitor with IC50 of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.
Donepezil (E2020) exerts a protective action against acute diisopropylfluorophosphate-poisoning in the mouse.

Physicochemical Properties

M.Wt 415.96
Formula C24H30ClNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride

References

1. Galli A, et al. Eur J Pharmacol. 1994 Apr 4;270(2-3):189-93.

2. Ohnishi A, et al. J Clin Pharmacol. 1993 Nov;33(11):1086-91.

3. Misson J, et al. J Clin Pharm Ther. 1997 Aug;22(4):251-5.

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