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Doramapimod

Chemical Structure : Doramapimod

CAS No.: 285983-48-4

Doramapimod (BIRB 796, BIRB-796, BIRB796)

Catalog No.: PC-42520Not For Human Use, Lab Use Only.

Doramapimod (BIRB-796) is a highly potent p38 MAPK inhibitor with Kd of 0.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Doramapimod (BIRB-796) is a highly potent p38 MAPK inhibitor with Kd of 0.1 nM.
Doramapimod (BIRB-796) displays no activity on ERK1, IKK2b, ZAP-70, EGFR, PKA, PKC, etc
Doramapimod (BIRB-796) shows inhibition of TNFα inTHP.1 with IC50 of 18 nM.
Doramapimod (BIRB-796) is orally active.

Physicochemical Properties

M.Wt 527.6572
Formula C31H37N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-

References

1. Pargellis C, et al. Nat Struct Biol. 2002 Apr;9(4):268-72.

2. Regan J, et al. J Med Chem. 2002 Jul 4;45(14):2994-3008.

3. Gruenbaum LM, et al. Biochem Pharmacol. 2009 Feb 1;77(3):422-32.

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