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Chemical Structure : Doravirine
CAS No.: 1338225-97-0
Catalog No.: PC-45074Not For Human Use, Lab Use Only.
Doravirine (MK-1439, MK1439) is a novel, highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 12, 9.7, and 9.7 nM against WT, K103N, and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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Doravirine (MK-1439, MK1439) is a novel, highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 12, 9.7, and 9.7 nM against WT, K103N, and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay.
Doravirine (MK-1439) shows excellent potency in suppressing the replication of WT virus with EC95 of 20 nM, as well as K103N, Y181C, and K103N/Y181C mutant viruses with EC95 of 43, 27, and 55 nM, respectively.
| M.Wt | 425.7491 | |
| Formula | C17H11ClF3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Benzonitrile, 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]- |
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1. Lai MT, et al. Antimicrob Agents Chemother. 2014;58(3):1652-63.
2. Côté B, et al. Bioorg Med Chem Lett. 2014 Feb 1;24(3):917-22.
3. Feng M, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):590-8.
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