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Dorzagliatin

Chemical Structure : Dorzagliatin

CAS No.: 1191995-00-2

Dorzagliatin (HMS-5552, HMS5552)

Catalog No.: PC-60040Not For Human Use, Lab Use Only.

Dorzagliatin (HMS-5552, HMS5552) is a novel potent, fourth-generation glucokinase (GK) activator.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dorzagliatin (HMS-5552, HMS5552) is a novel potent, fourth-generation glucokinase (GK) activator.
HMS-5552 exerts its antidiabetic effect by inhibiting insulin resistance and increasing insulin sensitivity, significantly increased GK expression.
HMS-5552 effectively improves GK activity and insulin resistance by targeting both the liver and pancreas in rat T2DM models.

Physicochemical Properties

M.Wt 462.931
Formula C22H27ClN4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide

References

1. Wang P, et al. J Diabetes Res. 2017;2017:5812607.

2. Xu H, et al. Drug Des Devel Ther. 2016 May 9;10:1619-26.

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