Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Dorzagliatin
CAS No.: 1191995-00-2
Catalog No.: PC-60040Not For Human Use, Lab Use Only.
Dorzagliatin (HMS-5552, HMS5552) is a novel potent, fourth-generation glucokinase (GK) activator.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $28 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Dorzagliatin (HMS-5552, HMS5552) is a novel potent, fourth-generation glucokinase (GK) activator.
HMS-5552 exerts its antidiabetic effect by inhibiting insulin resistance and increasing insulin sensitivity, significantly increased GK expression.
HMS-5552 effectively improves GK activity and insulin resistance by targeting both the liver and pancreas in rat T2DM models.
| M.Wt | 462.931 | |
| Formula | C22H27ClN4O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide |
|
1. Wang P, et al. J Diabetes Res. 2017;2017:5812607.
2. Xu H, et al. Drug Des Devel Ther. 2016 May 9;10:1619-26.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
