Dotinurad | URAT1 inhibitor | Probechem Biochemicals

Chemical Structure : Dotinurad

CAS No.: 1285572-51-1

Dotinurad (FYU-981, FYU981, URAT1 inhibitor)

Catalog No.: PC-60041Not For Human Use, Lab Use Only.

Dotinurad (FYU-981) is a potent and selective urate transporter 1 (URAT1) inhibitor with IC50 of 37.2 nM.

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$228	In stock
25 mg	$358	In stock
50 mg	$558	In stock
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Biological Activity

Dotinurad (FYU-981) is a potent and selective urate transporter 1 (URAT1) inhibitor with IC50 of 37.2 nM.

Dotinurad weakly inhibited ATP-binding cassette subfamily G member 2 (ABCG2), organic anion transporter 1 (OAT1), and OAT3, with IC50 values of 4.16, 4.08, and 1.32 μM, respectively, indicating higher selectivity for URAT1.

Dotinurad (1-30 mg/kg) decreased plasma urate levels and increased fractional excretion of urate (FEUA) in a dose-dependent manner in Cebus monkeys.

Dotinurad is a potent and selective urate reabsorption inhibitor is characterized by increased efficacy with decreasing plasma urate levels.

Physicochemical Properties

M.Wt	358.189
Formula	C14H9Cl2NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone

References

1. Tetsuya Taniguchi, et al. J Pharmacol Exp Ther. 2019 Oct;371(1):162-170.
2. Hosoya T, et al. Clin Exp Nephrol. 2020 Mar;24(Suppl 1):53-61.

Dotinurad (FYU-981, FYU981, URAT1 inhibitor)

Biological Activity

Physicochemical Properties

References

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