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Doxazosin

Chemical Structure : Doxazosin

CAS No.: 74191-85-8

Doxazosin (UK 33274)

Catalog No.: PC-27221Not For Human Use, Lab Use Only.

Doxazosin is a long-lasting, selective antagnist of α1-adrenoceptor antagonist receptors, shows potent apoptotic effect against prostate tumor epithelial cells, also has direct inhibitory effect on cholesterol synthesis independent of the LDL receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Doxazosin is a long-lasting, selective antagnist of α1-adrenoceptor antagonist receptors, shows potent apoptotic effect against prostate tumor epithelial cells, also has direct inhibitory effect on cholesterol synthesis independent of the LDL receptor.

Physicochemical Properties

M.Wt 451.48
Formula C23H25N5O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone

References

1. Tsukiyama H, et al. Drugs. 1988;36 Suppl 6:48-54.

2. Miura Y, et al. Am Heart J. 1988 Dec;116(6 Pt 2):1785-9.

3. Benning CM, et al. Cancer Res. 2002 Jan 15;62(2):597-602.

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