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Doxorubicin hydrochloride

Chemical Structure : Doxorubicin hydrochloride

CAS No.: 25316-40-9

Doxorubicin hydrochloride (Adriamycin)

Catalog No.: PC-49305Not For Human Use, Lab Use Only.

Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin, Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II.

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Biological Activity

Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin, Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II.
Doxorubicin is a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.
Doxorubicin reduces intracellular tau levels.
Doxorubicin also promotes formation of free radicals for the disruption of membrane lipids and DNA strands.
Doxorubicin fluorescence is quenched upon intercalation into the DNA; while binding to histones or partitioning into the phospholipid phase of PEG-phospholipid micelles or hydrophobic cores of polymeric micelles, increases Doxorubicin fluorescence.

Physicochemical Properties

M.Wt 579.99
Formula C27H29NO11.HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride

References

1. John L. Nitiss, et al. Nat Rev Cancer. 2009 May;9(5):338-50.
2. Hee-KyungRhee,et al. Bioorg Med Chem. 2007 Feb 15;15(4):1651-8.

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