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Chemical Structure : Doxorubicin hydrochloride
CAS No.: 25316-40-9
Catalog No.: PC-49305Not For Human Use, Lab Use Only.
Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin, Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 250 mg | $198 | In stock | |
| 1 g | Get quote |
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Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin, Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II.
Doxorubicin is a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.
Doxorubicin reduces intracellular tau levels.
Doxorubicin also promotes formation of free radicals for the disruption of membrane lipids and DNA strands.
Doxorubicin fluorescence is quenched upon intercalation into the DNA; while binding to histones or partitioning into the phospholipid phase of PEG-phospholipid micelles or hydrophobic cores of polymeric micelles, increases Doxorubicin fluorescence.
| M.Wt | 579.99 | |
| Formula | C27H29NO11.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride |
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1. John L. Nitiss, et al. Nat Rev Cancer. 2009 May;9(5):338-50.
2. Hee-KyungRhee,et al. Bioorg Med Chem. 2007 Feb 15;15(4):1651-8.
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