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Dronedarone

Chemical Structure : Dronedarone

CAS No.: 141626-36-0

Dronedarone (SR-33589)

Catalog No.: PC-46030Not For Human Use, Lab Use Only.

A multichannel blocker agent that has antiarrhythmic activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A multichannel blocker agent that has antiarrhythmic activity; reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats; reduces significantly the incidence of ventricular fibrillation (VF) in rats; mainly used for treatment of cardiac arrhythmias.

Heart Arrhythmia

Approved

Physicochemical Properties

M.Wt 556.7565
Formula C31H44N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-

References

1. Aimond F, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):415-24.

2. Sun W, et al. Circulation. 1999 Nov 30;100(22):2276-81.

3. Manakshe G, et al. Indian Heart J. 2012 Mar-Apr;64(2):182-6.

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