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Dronedarone hydrochloride

Chemical Structure : Dronedarone hydrochloride

CAS No.: 141625-93-6

Dronedarone hydrochloride (SR33589 hydrochloride)

Catalog No.: PC-45962Not For Human Use, Lab Use Only.

Dronedarone hydrochloride (SR33589) is a multichannel blocker agent that has antiarrhythmic activity, reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Dronedarone hydrochloride (SR33589) is a multichannel blocker agent that has antiarrhythmic activity, reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats.
Dronedarone reduces significantly the incidence of ventricular fibrillation (VF) in rats.
Dronedarone mainly used for treatment of cardiac arrhythmias.

Physicochemical Properties

M.Wt 593.2174
Formula C31H45ClN2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-, hydrochloride (1:1)

References

1. Aimond F, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):415-24.

2. Sun W, et al. Circulation. 1999 Nov 30;100(22):2276-81.

3. Manakshe G, et al. Indian Heart J. 2012 Mar-Apr;64(2):182-6.

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