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Chemical Structure : Droxinostat
CAS No.: 99873-43-5
Catalog No.: PC-43447Not For Human Use, Lab Use Only.
Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.
Droxinostat (NS-41080) does not inhibit HDAC1, HDAC2, HDAC4, HDAC5, HDAC7, HDAC9, and HDAC10 with IC50 of >20 uM.
Droxinostat (NS-41080) sensitizes malignant cells to death receptor ligands FAS and TRAIL sensitization with IC50 of 20 and 39 uM, respectively.
Droxinostat (NS-41080) decreases the expression of the caspase-8 inhibitor FLIP, downregulates c-FLIP(L) and c-FLIP(S) mRNA and protein levels, causes PARP degradation, reduces cell survival, and induces apoptosis in MCF-7 breast cancer cells.
| M.Wt | 243.69 | |
| Formula | C11H14ClNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Butanamide, 4-(4-chloro-2-methylphenoxy)-N-hydroxy- |
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1. Wood TE, et al. Mol Cancer Ther. 2010 Jan;9(1):246-56.
2. Bijangi-Vishehsaraei K, et al. Mol Cell Biochem. 2010 Sep;342(1-2):133-142.
3. McCourt C, et al. Clin Cancer Res. 2012 Jul 15;18(14):3822-33.
4. Liu J, et al. Transl Oncol. 2016 Feb;9(1):70-78.
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