Catalog No.: PC-20940Not For Human Use, Lab Use Only.
Drp1 inhibitor SC9 (Drp1 SWAG ligand SC9) is a small molecule binder of dynamin-related protein 1 (Drp1) allosteric site switch I-adjacent groove (SWAG), inhibits GTPase activity of Drp1 (IC50=270 nM) and inhibits Drp1-Fis1 interaction in cells.
Drp1 inhibitor SC9 (Drp1 SWAG ligand SC9) is a small molecule binder of dynamin-related protein 1 (Drp1) allosteric site switch I-adjacent groove (SWAG), inhibits GTPase activity of Drp1 (IC50=270 nM) and inhibits Drp1-Fis1 interaction in cells.
SC9 act as uncompetitive inhibitors of WT Drp1, SC9 (1 uM) reduced both Km and Vmax of Drp1.
SC9 reduces LPS-induced mitochondrial dysfunction in H9c2 cells.
SC9 blocks stress-induced Drp1 oligomerization, inhibits LPS-induced mitochondrial membrane depolarization in H9c2 cells with IC50 of 750 nM.
SC9 blocks mitochondrial translocation of Drp1 to the mitochondria by selectively inhibiting Drp1-Fis1 interaction.
SC9 (10 mg/kg, i.p.) effectively inhibits LPS-induced mortality in mouse model of endotoxemia.
