Chemical Structure : Drp1 inhibitor SC9
CAS No.:
851471-44-8
Drp1 inhibitor SC9
(Drp1 SWAG ligand SC9)
Catalog No.: PC-20940Not For Human Use, Lab Use Only.
Drp1 inhibitor SC9 (Drp1 SWAG ligand SC9) is a small molecule binder of dynamin-related protein 1 (Drp1) allosteric site switch I-adjacent groove (SWAG), inhibits GTPase activity of Drp1 (IC50=270 nM) and inhibits Drp1-Fis1 interaction in cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Drp1 inhibitor SC9 (Drp1 SWAG ligand SC9) is a small molecule binder of dynamin-related protein 1 (Drp1) allosteric site switch I-adjacent groove (SWAG), inhibits GTPase activity of Drp1 (IC50=270 nM) and inhibits Drp1-Fis1 interaction in cells.
SC9 act as uncompetitive inhibitors of WT Drp1, SC9 (1 uM) reduced both Km and Vmax of Drp1.
SC9 reduces LPS-induced mitochondrial dysfunction in H9c2 cells.
SC9 blocks stress-induced Drp1 oligomerization, inhibits LPS-induced mitochondrial membrane depolarization in H9c2 cells with IC50 of 750 nM.
SC9 blocks mitochondrial translocation of Drp1 to the mitochondria by selectively inhibiting Drp1-Fis1 interaction.
SC9 (10 mg/kg, i.p.) effectively inhibits LPS-induced mortality in mouse model of endotoxemia.
Physicochemical Properties
|
M.Wt
|
466.52
|
|
Formula
|
C21H22N8O3S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
O=C(N(C1=C(N)N(CC2=CC=CC=C2)C(NC1=O)=O)C)CSC3=NN4C(C)=CC(C)=NC4=N3
|
References
1. Rios L, et al. Nat Commun. 2023 Jul 19;14(1):4356.
Contact Us
sales@probechem.com
