Dupilumab
(Anti-human IL-4,IL-13 mAb, human IgG1-Kappa; REGN-668; SAR-231893)
Catalog No.: PC-Ab1085Not For Human Use, Lab Use Only.
Dupilumab (REGN-668, SAR-231893) is a human monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4Rα subunit shared by the IL-4 and IL-13 receptor complexes. Dupilumab down-regulates TH2 inflammation in a variety of allergic disorders, including atopic dermatitis, asthma and possibly other allergic diseases. Besides, Dupilumab was shown to inhibit IgE production by ex-vivo B cells induced by IL-4 treatment..
Dupilumab (REGN-668, SAR-231893) is a human monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4Rα subunit shared by the IL-4 and IL-13 receptor complexes. Dupilumab down-regulates TH2 inflammation in a variety of allergic disorders, including atopic dermatitis, asthma and possibly other allergic diseases. Besides, Dupilumab was shown to inhibit IgE production by ex-vivo B cells induced by IL-4 treatment.
Physicochemical Properties
M.Wt
Formula
Human IgG1-Kappa
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
PBS, pH 7.0
Contains no stabilizers or preservatives
