Catalog No.: PC-38781Not For Human Use, Lab Use Only.
Dusquetide (SGX-942, SGX94) is a 5-amino acid peptide, cell membrane penetrant innate defense regulator (IDR) that modulates the innate immune response to both PAMPs and DAMPs, targets the ZZ domain of p62 and modulates the p62-RIP1 complex.
Dusquetide (SGX-942, SGX94) is a 5-amino acid peptide, cell membrane penetrant innate defense regulator (IDR), targets the ZZ domain of p62 and modulates the p62-RIP1 complex.
Dusquetide penetrates the cell membrane and associates with p62 in vivo.
Dusquetide binding modulates the p62-RIP1 complex, increases p38 phosphorylation, and enhances CEBP/B expression without activating autophagy.
Dusquetide reduces the duration of mucositis in preclinical animal models, and in Phase 2a clinical studys.
