Dutacatib (AFG495) | Cathepsin K inhibitor

Chemical Structure : Dutacatib

Dutacatib (AFG495, AFG-495)

Catalog No.: PC-20203Not For Human Use, Lab Use Only.

Dutacatib (AFG495) is potent, selective and non-covalent cathepsin K inhibitor with IC50 of 3-6 nM (human CatK), shows excellent selectivity profile versus human cathepsins L and S.

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Biological Activity

Dutacatib (AFG495) is potent, selective and non-covalent cathepsin K inhibitor with IC50 of 3-6 nM (human CatK), shows excellent selectivity profile versus human cathepsins L and S.

Physicochemical Properties

M.Wt	421.55
Formula	C23H31N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[2-cyano-4-(2,2-dimethylpropylamino)pyrimidin-5-yl]methyl]-4-(4-methylpiperazin-1-yl)benzamide

References

1. Eva Altmann, et al. J Med Chem. 2002 Jun 6;45(12):2352-4.

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Dutacatib (AFG495, AFG-495)

Biological Activity

Physicochemical Properties

References

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