Duvelisib (IPI-145, INK-1197)

Chemical Structure : Duvelisib

CAS No.: 1201438-56-3

Catalog No.: PC-45169Not For Human Use, Lab Use Only.

Duvelisib (IPI-145, INK-1197) is a potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.

Packing	Price	Stock
5 mg	$98	In stock
25 mg	$188	In stock
50 mg	$298	In stock
100 mg	$458	In stock
250 mg		Get quote

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Biological Activity

Duvelisib (IPI-145, INK-1197) is a potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.
Duvelisib (IPI-145, INK-1197) displays high selectivity for PI3K δ/γ than other protein kinases.
Duvelisib (IPI-145, INK-1197) exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation.
Duvelisib (IPI-145, INK-1197) exhibits potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models.

Physicochemical Properties

M.Wt	416.863
Formula	C22H17ClN6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 41 mg/mL
Chemical Name/SMILES	1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-

References

1. Winkler DG, et al. Chem Biol. 2013 Nov 21;20(11):1364-74.

2. Boyle DL, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80.

3. Dong S, et al. Blood. 2014 Dec 4;124(24):3583-6.