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Chemical Structure : Dynein2-IN-37
Catalog No.: PC-62397Not For Human Use, Lab Use Only.
Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM).
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Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM).
Dynein2-IN-37 directly targets the heavy chains of both dynein isoforms and explore the structure-activity landscape of these inhibitors in vitro and in cells.
Dynein2-IN-37 inhibits retrograde ciliary GLI2 transport more strongly than ciliobrevin A, effectively disrupts Hedgehog signaling, intraflagellar transport, and ciliogenesis.
| M.Wt | 478.329 | |
| Formula | C25H17Cl2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. See SK, et al. ACS Chem Biol. 2016 Jan 15;11(1):53-60.
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