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Chemical Structure : Dyngo-4a
CAS No.: 1256493-34-1
Catalog No.: PC-20783Not For Human Use, Lab Use Only.
Dyngo-4a (Hydroxy Dynasore) is a potent Dynasore analog and dynamin inhibitor with IC50 of 0.38 and 2.6 uM for dynamin I and dynamin II, respectively, inhibits endocytosis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 1 g | Get quote |
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Dyngo-4a (Hydroxy Dynasore) is a potent Dynasore analog and dynamin inhibitor with IC50 of 0.38 and 2.6 uM for dynamin I and dynamin II, respectively, inhibits endocytosis.
Dyngo-4a (20 uM)prevents SNAP25 cleavage by BoNT/A in cultured hippocampal neurons.
Dyngo-4a provides protection again BoNT/A-induced paralysis in the phrenic nerve-hemidiaphragm twitch model and in vivo.
| M.Wt | 338.32 | |
| Formula | C18H14N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-3-hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide |
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1. Harper CB, et al. J Biol Chem. 2011 Oct 14;286(41):35966-35976.
2. Howes M. T., et al. J. Cell Biol. 190, 675–691
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