Chemical Structure : Dynole 34-2
Catalog No.: PC-63240Not For Human Use, Lab Use Only.
Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively; induces cytokinesis failure at the point of abscission, consistent with inhibition of dynamin while not affecting other cell cycle stages in cancer cells; disrupt midbody localization of calcineurin but not phospho-dynII and γ-tubulin, inhibits growth in a range of cancer cell lines with IC50 of 4.0 to 36.7 uM in MTT assays; Dynole 34-2 is a novel antimitotic compound acting specifically at the abscission stage.
M.Wt | 408.59 | |
Formula | C25H36N4O | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
1. Chircop M, et al. Mol Cancer Ther. 2011 Sep;10(9):1553-62.
2. Hill TA, et al. J Med Chem. 2009 Jun 25;52(12):3762-73.
3. Robertson MJ, et al. Nat Protoc. 2014 Apr;9(4):851-70.
4. Jackson J, et al. Mol Psychiatry. 2015 Jul;20(7):810-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright