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Chemical Structure : Dynole 34-2
CAS No.: 1128165-88-7
Catalog No.: PC-63240Not For Human Use, Lab Use Only.
Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.
Dynole 34-2 induces cytokinesis failure at the point of abscission, consistent with inhibition of dynamin while not affecting other cell cycle stages in cancer cell.
Dynole 34-2 disrupt midbody localization of calcineurin but not phospho-dynII and γ-tubulin, inhibits growth in a range of cancer cell lines with IC50 of 4.0 to 36.7 uM in MTT assays.
Dynole 34-2 is a novel antimitotic compound acting specifically at the abscission stage.
| M.Wt | 408.59 | |
| Formula | C25H36N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide |
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1. Chircop M, et al. Mol Cancer Ther. 2011 Sep;10(9):1553-62.
2. Hill TA, et al. J Med Chem. 2009 Jun 25;52(12):3762-73.
3. Robertson MJ, et al. Nat Protoc. 2014 Apr;9(4):851-70.
4. Jackson J, et al. Mol Psychiatry. 2015 Jul;20(7):810-9.
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