Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.
Dynole 34-2 induces cytokinesis failure at the point of abscission, consistent with inhibition of dynamin while not affecting other cell cycle stages in cancer cell.
Dynole 34-2 disrupt midbody localization of calcineurin but not phospho-dynII and γ-tubulin, inhibits growth in a range of cancer cell lines with IC50 of 4.0 to 36.7 uM in MTT assays.
Dynole 34-2 is a novel antimitotic compound acting specifically at the abscission stage.
