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Dynole 34-2

Chemical Structure : Dynole 34-2

CAS No.: 1128165-88-7

Dynole 34-2

Catalog No.: PC-63240Not For Human Use, Lab Use Only.

Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively; induces cytokinesis failure at the point of abscission, consistent with inhibition of dynamin while not affecting other cell cycle stages in cancer cells; disrupt midbody localization of calcineurin but not phospho-dynII and γ-tubulin, inhibits growth in a range of cancer cell lines with IC50 of 4.0 to 36.7 uM in MTT assays; Dynole 34-2 is a novel antimitotic compound acting specifically at the abscission stage.

Physicochemical Properties

M.Wt 408.59
Formula C25H36N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide

References

1. Chircop M, et al. Mol Cancer Ther. 2011 Sep;10(9):1553-62.

2. Hill TA, et al. J Med Chem. 2009 Jun 25;52(12):3762-73.

3. Robertson MJ, et al. Nat Protoc. 2014 Apr;9(4):851-70.

4. Jackson J, et al. Mol Psychiatry. 2015 Jul;20(7):810-9.

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