E-2012 |CAS:870843-42-8 Probechem Biochemicals

Chemical Structure : E-2012

CAS No.: 870843-42-8

Catalog No.: PC-42071Not For Human Use, Lab Use Only.

E-2012 (E2012) is a potent, second-generation γ-secretase modulator that decreases Aβ(1-39), Aβ(1-40) and A(1-42), and increases Aβ(1-37).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

E-2012 (E2012) is a potent, second-generation γ-secretase modulator that decreases Aβ(1-39), Aβ(1-40) and A(1-42), and increases Aβ(1-37).

M.Wt	419.4912
Formula	C25H26FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Piperidinone, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-, (3E)-

1. Portelius E, et al. J Alzheimers Dis. 2010;21(3):1005-12.

2. Borgegard T, et al. J Biol Chem. 2012 Apr 6;287(15):11810-9.

3. Borghys H, et al. J Alzheimers Dis. 2012;28(4):809-22.