E-2212 | γ-secretase modulator | Probechem Biochemicals

Chemical Structure : E-2212

Catalog No.: PC-22497Not For Human Use, Lab Use Only.

E-2212 is a potent, selective γ-secretase modulator with Aβ42 IC50 of 7 nM.

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Biological Activity

E-2212 is a potent, selective γ-secretase modulator with Aβ42 IC50 of 7 nM.

M.Wt	480.50
Formula	C25H23F3N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-2-(2-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)vinyl)-8-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

1. Pettersson M, et al. J Med Chem. 2024 Jun 7. doi: 10.1021/acs.jmedchem.4c00580.