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Chemical Structure : E-4031
CAS No.: 113559-13-0
Catalog No.: PC-63156Not For Human Use, Lab Use Only.
E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).
E-4031 reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents.
| M.Wt | 474.441 | |
| Formula | C21H29Cl2N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-[2-(6-methyl-2pyridyl)ethyl]-4-(4-methylsulfonyl aminobenzoyl)piperidine dihydrochloride |
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1. Katoh H, et al. J Pharmacol Exp Ther. 1990 Jun;253(3):1077-82.
2. Sano T, et al. Br J Pharmacol. 1990 Mar;99(3):577-81.
3. Lynch JJ Jr, et al. J Cardiovasc Pharmacol. 1990 May;15(5):764-75.
4. Smith JL, et al. Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C919-30.
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