Chemical Structure : E-4031
CAS No.:
113559-13-0
E-4031
(E4031)
Catalog No. : PC-63156Not For Human Use, Lab Use Only.
E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6315601
Biological Activity
E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG ) and blocks the rapid delayed-rectifier K+ current (IKr).
Physicochemical Properties
M.Wt
474.441
Formula
C21H29Cl2N3O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-[2-(6-methyl-2pyridyl)ethyl]-4-(4-methylsulfonyl aminobenzoyl)piperidine dihydrochloride
References
1. Katoh H, et al. J Pharmacol Exp Ther.
2. Sano T, et al. Br J Pharmacol.
3. Lynch JJ Jr, et al. J Cardiovasc Pharmacol.
4. Smith JL, et al. Am J Physiol Cell Physiol
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