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E-5842

Chemical Structure : E-5842

CAS No.: 177945-46-9

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E-5842 (E5842)

Catalog No.: PC-63203Not For Human Use, Lab Use Only.

E-5842 (E5842) is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    E-5842 (E5842) is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo.
    E-5842  increases phospholipase C (PLC) activity in the striatum and the hippocampus, increased levels of Fos in the medial prefrontal cortex and the nucleus accumbens in rat forebrain.

    Physicochemical Properties

    M.Wt 300.381
    Formula C17H21FN4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-fluorophenil)-1,2,3,6- tetrahydro-1-[4-(1,2,4-triazol-1-il)butyl] pyridine citrate

    References

    1. Sánchez-Arroyos R, et al. Eur J Pharmacol. 1999 Jul 28;378(1):31-7.

    2. Romero G, et al. Neurosci Lett. 2000 Sep 1;290(3):189-92.

    3. Guitart X, et al. Neuropsychopharmacology. 2000 Nov;23(5):539-46.

    4. Guitart X, et al. Eur J Pharmacol. 1998 Dec 18;363(2-3):127-30.

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