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E-5842 hydrochloride

Chemical Structure : E-5842 hydrochloride

CAS No.: 177945-45-8

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E-5842 hydrochloride (E5842)

Catalog No.: PC-63204Not For Human Use, Lab Use Only.

E-5842 is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    E-5842 hydrochloride (E5842) is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo.
    E-5842 increases phospholipase C (PLC) activity in the striatum and the hippocampus, increased levels of Fos in the medial prefrontal cortex and the nucleus accumbens in rat forebrain.

    Physicochemical Properties

    M.Wt 336.839
    Formula C17H22ClFN4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-(1H-1,2,4-triazol-1-yl)butyl)-4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride

    References

    1. Sánchez-Arroyos R, et al. Eur J Pharmacol. 1999 Jul 28;378(1):31-7.

    2. Romero G, et al. Neurosci Lett. 2000 Sep 1;290(3):189-92.

    3. Guitart X, et al. Neuropsychopharmacology. 2000 Nov;23(5):539-46.

    4. Guitart X, et al. Eur J Pharmacol. 1998 Dec 18;363(2-3):127-30.

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