Catalog No.: PC-24084Not For Human Use, Lab Use Only.
E7766 diammonium salt is a macrocycle-bridged STING agonist with ITC Kd of 40 nM, exhibits broad pan-genotypic activity in all major human STING variants.
E7766 diammonium salt is a macrocycle-bridged STING agonist with ITC Kd of 40 nM, exhibits broad pan-genotypic activity in all major human STING variants. E7766 has higher binding affinity than 2′,3′-cGAMP. E7766 induces IFNβ expression in primary human peripheral blood mononuclear cells harboring any of seven major STING genotypes with EC50 values of 0.15 to 0.79 uM. E7766 is highly efficacious in CT26 live metastasis tumor model.
Physicochemical Properties
M.Wt
780.66
Formula
C24H26F2N10O8P2S2.2H3N
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Adenosine, N,N′′-(2E)-2-butene-1,4-diyl-[P(R)]-2′-deoxy-2′-fluoro-5′-O-[(S)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3′→5′)-2′-deoxy-2′-fluoro-, cyclic nucleotide, ammonium salt (1:2)
References
1. Kim DS, et al. ChemMedChem. 2021 Jun 7;16(11):1740-1743.
2. Huang KC, et al. Mol Cancer Ther. 2022 Jun 1;21(6):914-924.
