Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Autophagy-EAD1
EAD1

Chemical Structure : EAD1

CAS No.: 1644388-26-0

Add to Favorites

EAD1 (Autophagy inhibitor EAD1)

Catalog No.: PC-49174Not For Human Use, Lab Use Only.

EAD1 is a potent autophagy inhibitor, exhibits growth inhibitory activity in human cancer cell lines, H460 and HCC827 NSCLC and BxPC3 pancreatic cancer cells with IC50 of 11, 7.6, and 5.8 uM, respectively.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EAD1 is a potent autophagy inhibitor, exhibits growth inhibitory activity in human cancer cell lines, H460 and HCC827 NSCLC and BxPC3 pancreatic cancer cells with IC50 of 11, 7.6, and 5.8 uM, respectively.
    EAD1 increases punctate LC3 expression in lung cancer cells.
    EAD1 has increased growth inhibitory and autophagy-inducing potencies compared to CQ and HCQ.

    Physicochemical Properties

    M.Wt 484.429
    Formula C24H27Cl2N7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-[2-[[[1-[(4-Chlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]ethyl]-N2-(7-chloro-4-quinolinyl)-N1-methyl-1,2-ethanediamine

    References

    1. Nordstrøm LU, et al. ACS Med Chem Lett. 2015 Jan 8;6(2):134-9.

    2. Yazal T, et al. Mol Cancer Ther. 2022 Jan;21(1):79-88.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: