Catalog No.: PC-42087Not For Human Use, Lab Use Only.
EAI-045 (EAI045) is a potent, mutant-selective allosteric EGFR inhibitor with IC50 of 3 nM for double mutant L858R/T790M in biochemical assays at 1 mM ATP.
EAI-045 (EAI045) is a potent, mutant-selective allosteric EGFR inhibitor with IC50 of 3 nM for double mutant L858R/T790M in biochemical assays at 1 mM ATP.
EAI-045 (EAI045) displays >1000-fold selectivity versus wild type EGFR, also inhibits L858R and T790M with IC50 of 76 and 49 nM.
EAI-045 (EAI045) potently inhibits EGFR Y1173 phosphorylation in H1975 cells (EC50=2 nM).
EAI-045 (EAI045) exhibits true mechanistic synergy combined with cetuximab in mouse models of lung cancer driven by EGFR(L858R/T790M) and by EGFR(L858R/T790M/C797S).
