Chemical Structure : EBET-1055
CAS No.:
3031540-65-2
EBET-1055
(ER-001326054-000, EBET1055)
Catalog No.: PC-22215Not For Human Use, Lab Use Only.
EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC.
EBET-1055 is highly potent in both PC-3 and PC-42 organoids.
EBET-1055 is composed of BET inhibitor (EBET-590), an E3 ubiquitin ligase ligand, and a linker.
EBET-1055 decreased the phosphorylation levels of STAT3 Y705, SMAD2 S465/467, and SMAD3 S423/425 in PDAC cells.
Physicochemical Properties
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M.Wt
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923.04
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Formula
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C51H54N8O9
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(2-(4-((1-(4-(1-cyclopropoxy-2-hydroxy-1-phenylethyl)-6-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)quinazolin-2-yl)piperidin-4-yl)methyl)piperazin-1-yl)-2-oxoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
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References
1. Nakazawa Y, et al. Nat Commun. 2024 Mar 11;15(1):2192.
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