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Chemical Structure : EBET-1055
Catalog No.: PC-22215Not For Human Use, Lab Use Only.
EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC.
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EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC.
EBET-1055 is highly potent in both PC-3 and PC-42 organoids.
EBET-1055 is composed of BET inhibitor (EBET-590), an E3 ubiquitin ligase ligand, and a linker.
EBET-1055 decreased the phosphorylation levels of STAT3 Y705, SMAD2 S465/467, and SMAD3 S423/425 in PDAC cells.
| M.Wt | 923.04 | |
| Formula | C51H54N8O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nakazawa Y, et al. Nat Commun. 2024 Mar 11;15(1):2192.
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