EBET-1593 | BET degrader | Probechem Biochemicals

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Chemical Structure : EBET-1593

EBET-1593 (ER-001388472-000)

Catalog No.: PC-22219Not For Human Use, Lab Use Only.

EBET-593 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EBET-593 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC.

Physicochemical Properties

M.Wt	904.09
Formula	C52H57N9O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(3-((1'-(4-(1-cyclopropoxy-2-hydroxy-1-phenylethyl)-6-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)quinazolin-2-yl)-4-methyl-[1,4'-bipiperidin]-4-yl)amino)prop-1-yn-1-yl)-2-methoxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione

References

1. Nakazawa Y, et al. Nat Commun. 2024 Mar 11;15(1):2192.

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EBET-1593 (ER-001388472-000)

Biological Activity

Physicochemical Properties

References

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