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Chemical Structure : EBI-907
Catalog No.: PC-62702Not For Human Use, Lab Use Only.
EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.
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EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.
EBI-907 shows no anti-proliferative effects on the growth of Calu-6 cells carrying a wild-type B-Raf, exhibiting at least 40-fold (455 nM) selectivity towards B-RafV600E-dependent cells lines.
EBI-907 demonstrates excellent in vivo efficacy in B-Raf(V600E) dependent Colo-205 tumor xenograft models in mouse.
| M.Wt | 506.95 | |
| Formula | C23H21ClF2N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lu B, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-23.
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