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EBI-907

Chemical Structure : EBI-907

CAS No.: 1581764-31-9

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EBI-907 (EBI907)

Catalog No.: PC-62702Not For Human Use, Lab Use Only.

EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.
    EBI-907 shows no anti-proliferative effects on the growth of Calu-6 cells carrying a wild-type B-Raf, exhibiting at least 40-fold (455 nM) selectivity towards B-RafV600E-dependent cells lines.
    EBI-907 demonstrates excellent in vivo efficacy in B-Raf(V600E) dependent Colo-205 tumor xenograft models in mouse.

    Physicochemical Properties

    M.Wt 506.95
    Formula C23H21ClF2N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-chloro-3-(1-cyclopropyl-8-methoxy-3H-pyrazolo[3,4-c]isoquinolin-7-yl)-4-fluorophenyl)-3-fluoropropane-1-sulfonamide

    References

    1. Lu B, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-23.

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