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EBL-3647

Chemical Structure : EBL-3647

CAS No.: 2851907-60-1

EBL-3647 (EBL3647)

Catalog No.: PC-22092Not For Human Use, Lab Use Only.

EBL-3647 is a novel LpxH inhibitor with IC50 of 2.2 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 0.5 mg/mL).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EBL-3647 is a novel LpxH inhibitor with IC50 of 2.2 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 0.5 mg/mL).
EBL-3647 has potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae.
EBL-3647 has potent in vitro activity against a diverse range of clinical E. coli and K. pneumoniae isolates, irrespective of the resistance genotype.

Physicochemical Properties

M.Wt 667.80
Formula C30H37N9O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((3-(aminomethyl)azetidin-1-yl)methyl)-N-(4-((4-(4-cyano-6-methylpyrimidin-2-yl)piperazin-1-yl)sulfonyl)phenyl)-2-(N-methylmethylsulfonamido)benzamide

References

1. Huseby DL, et al. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121.

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