EC-216 | m-nAChR PAM | Probechem Biochemicals

Chemical Structure : EC-216

EC-216 (EC216)

Catalog No.: PC-27339Not For Human Use, Lab Use Only.

EC-216 is a potent positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR), increases ACh-induced current in human myoblasts, potentiates the muscle ACh receptor through a membrane pocket.

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Biological Activity

Physicochemical Properties

M.Wt	559.54
Formula	C24H16F3N5O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-hydroxy-2-methyl-N-(5-(2-phenylpyrimidin-5-yl)-4-(trifluoromethyl)thiazol-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide

References

1. Huanhuan Li, et al. Nature. 2026 Jul 1. doi: 10.1038/s41586-026-10706-1.

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EC-216 (EC216)

Biological Activity

Physicochemical Properties

References

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