EC-70124 is a multikinase inhibitor with potent activity against several AML related kinases including FLT3, JAK, SYK or Pim kinases (Kd<10 nM).
EC-70124 inhibits 7 out of 9 FLT3 mutants, also acts as a dual STAT3/NF-kB inhibitor, reverting both tumorigenic and stem cell properties in prostate cancer.
EC-70124 inhibits AML cell proliferation and induces cell cycle arrest and apoptosis.
EC-70124 in vivo oral treatment causes complete regression in AML tumor xenograft models, and ex vivo inhibits proliferation in AML patient blasts at biochemically relevant doses.
