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EDP-938

Chemical Structure : EDP-938

CAS No.: 2070852-76-3

EDP-938 (Zelicapavir, EDP938)

Catalog No.: PC-23057Not For Human Use, Lab Use Only.

Zelicapavir (EDP-938) is a potent RSV viral nucleoprotein (N) inhibitor of both RSV-A and RSV-B activity, inhibits RSV induced CPE with EC50 of 52 nM in HEp-2 cells.

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Biological Activity

Zelicapavir (EDP-938) is a potent RSV viral nucleoprotein (N) inhibitor of both RSV-A and RSV-B activity, inhibits RSV induced CPE with EC50 of 52 nM in HEp-2 cells.
Zelicapavir (EDP-938) is highly active against all RSV-A and B laboratory strains and clinical isolates tested in vitro in various cell lines and assays, with EC50 of 21, 23 and 64 nM against Long (A), M37 (A) and VR-955 (B) strains, respectively, in the primary human bronchial epithelial cells (HBECs).
Zelicapavir (EDP-938) effectively blocks RSV replication by targeting a post-entry replication stage of the viral life cycle.

Physicochemical Properties

M.Wt 549.51
Formula C27H22F3N7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-3-[[5-[3-(4-morpholinyl)-5-(trifluoromethyl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]amino]-5-phenyl-, (3S)-

References

1. Rhodin MHJ, et al. PLoS Pathog. 2021 Mar 15;17(3):e1009428.

2. Ahmad A, et al. N Engl J Med. 2022 Feb 17;386(7):655-666.

3. Patent WO2017015449.

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