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EF-1502

Chemical Structure : EF-1502

CAS No.: 684645-54-3

EF-1502 (EF1502)

Catalog No.: PC-26893Not For Human Use, Lab Use Only.

EF-1502 (EF1502) is a selective inhibitor of GABA transporter GAT-1/BGT-1, noncompetitively inhibits both mGAT1 and the betaine/GABA transporter mGAT2 (BGT-1)) with Ki of 4 uM and 5 uM respectively, is inactive at GAT3 and GAT4.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EF-1502 (EF1502) is a selective inhibitor of GABA transporter GAT-1/BGT-1, noncompetitively inhibits both mGAT1 and the betaine/GABA transporter mGAT2 (BGT-1)) with Ki of 4 uM and 5 uM respectively, is inactive at GAT3 and GAT4.

Physicochemical Properties

M.Wt 414.58
Formula C22H26N2O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)(methyl)amino)-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol

References

1. White HS, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):866-74.

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