EGFR triple mutant inhibitor 31

Chemical Structure : EGFR triple mutant inhibitor 31

Catalog No.: PC-23646Not For Human Use, Lab Use Only.

EGFR triple mutant inhibitor 31 is a potent, mutant-selective inhibitor of EGFR L858R/T790M/C797S with Ki of 2.1 nM, inhibits EGFR del19/T790M/C797S in a Ba/F3 cellular assay with IC50 of 56.9 nM.

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Biological Activity

EGFR triple mutant inhibitor 31 is a potent, mutant-selective inhibitor of EGFR L858R/T790M/C797S with Ki of 2.1 nM, inhibits EGFR del19/T790M/C797S in a Ba/F3 cellular assay with IC50 of 56.9 nM.

Physicochemical Properties

M.Wt	524.65
Formula	C27H37FN8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(5S,8r)-8-(2-Ethyl-6-((2-((3S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-imidazo[1,2-b]pyrazol-1-yl)-2-methyl-2-azaspiro[4.5]decan-1-one

References

1. Igawa H, et al. J Med Chem. 2024 Dec 12. doi: 10.1021/acs.jmedchem.4c01405.

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