EGFR triple mutant inhibitor 31

Chemical Structure : EGFR triple mutant inhibitor 31

Catalog No.: PC-23646Not For Human Use, Lab Use Only.

EGFR triple mutant inhibitor 31 is a potent, mutant-selective inhibitor of EGFR L858R/T790M/C797S with Ki of 2.1 nM, inhibits EGFR del19/T790M/C797S in a Ba/F3 cellular assay with IC50 of 56.9 nM.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

EGFR triple mutant inhibitor 31 is a potent, mutant-selective inhibitor of EGFR L858R/T790M/C797S with Ki of 2.1 nM, inhibits EGFR del19/T790M/C797S in a Ba/F3 cellular assay with IC50 of 56.9 nM.

Physicochemical Properties

M.Wt	524.65
Formula	C27H37FN8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5S,8r)-8-(2-Ethyl-6-((2-((3S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-imidazo[1,2-b]pyrazol-1-yl)-2-methyl-2-azaspiro[4.5]decan-1-one

References

1. Igawa H, et al. J Med Chem. 2024 Dec 12. doi: 10.1021/acs.jmedchem.4c01405.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com