EI-1071 (Enrupatinib) is a potent, selective brain-penetrant and orally bioavailable colony stimulating factor-1 receptor (CSF-1R, c-FMS) inhibitor.
EI-1071 induced significant changes in microglial homeostasis, neuroinflammation, and neuronal injuries.
EI-1071 is effective in reducing activated microglia, neuroinflammation and neuronal injuries, resulting in a significant improvement of memory function in the 5xFAD model.
