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Chemical Structure : EMD386088
Catalog No.: PC-20844Not For Human Use, Lab Use Only.
EMD386088 is a potent, selective 5-HT6 receptor agonist with EC50 of 1.0 nM.
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EMD386088 is a potent, selective 5-HT6 receptor agonist with EC50 of 1.0 nM.
EMD386088 displays selectivity over other 5-HT receptors (IC50 values are 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively.
EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.
| M.Wt | 246.74 | |
| Formula | C14H15ClN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mattsson et al. Bioorg.Med.Chem.Lett., 2005;15:4230.
2. Nikiforuk A, et al. Psychopharmacology (Berl). 2011 Oct;217(3):411-8.
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