EMD386088 | 5-HT6 agonist | Probechem Biochemicals

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Chemical Structure : EMD386088

EMD386088 (EMD 386088)

Catalog No.: PC-20844Not For Human Use, Lab Use Only.

EMD386088 is a potent, selective 5-HT6 receptor agonist with EC50 of 1.0 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EMD386088 is a potent, selective 5-HT6 receptor agonist with EC50 of 1.0 nM.
EMD386088 displays selectivity over other 5-HT receptors (IC50 values are 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively.
EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.

Physicochemical Properties

M.Wt	246.74
Formula	C14H15ClN2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CC(N1)=C(C2=CCNCC2)C3=C1C=CC(Cl)=C3

References

1. Mattsson et al. Bioorg.Med.Chem.Lett., 2005;15:4230.

2. Nikiforuk A, et al. Psychopharmacology (Berl). 2011 Oct;217(3):411-8.

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EMD386088 (EMD 386088)

Biological Activity

Physicochemical Properties

References

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