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Chemical Structure : EMD527040
Catalog No.: PC-49394Not For Human Use, Lab Use Only.
EMD527040 (EMD 527040) is a potent, specific, nonpeptidic inhibitor of αvβ6 integrin, inhibits binding of recombinant αvβ6 to fibronectin at 6 nM as compared to >9.5 μM for αvβ3 and αvβ5 integrins.
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EMD527040 (EMD 527040) is a potent, specific, nonpeptidic inhibitor of αvβ6 integrin, inhibits binding of recombinant αvβ6 to fibronectin at 6 nM as compared to >9.5 μM for αvβ3 and αvβ5 integrins.
EMD527040 attenuated bile ductular proliferation and peribiliary collagen deposition by 40%-50%, induced down-regulation of fibrogenic and up-regulation of fibrolytic genes, and improved liver architecture and function.
EMD527040 reduced activated cholangiocyte proliferation, their adhesion to fibronectin, and endogenous activation of TGF-beta1 by 50% but did not affect bile duct apoptosis.
EMD527040 reduced expression of profibrotic markers and reduced fibrosis formation in DSG2-W2A mutation in arrhythmogenic cardiomyopathy (ACM) animal model.
| M.Wt | 587.498 | |
| Formula | C29H32Cl2N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goodman SL, et al. J Med Chem. 2002;45:1045-1051.
2. Patsenker E, et al. Gastroenterology. 2008 Aug;135(2):660-70.
3. Camilla Schinner, et al. Circulation. 2022 Oct 21. doi: 10.1161/CIRCULATIONAHA.121.057329.
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