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Chemical Structure : ENPP1 inhibitor 29f
Catalog No.: PC-21326Not For Human Use, Lab Use Only.
ENPP1 inhibitor 29f is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM.
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ENPP1 inhibitor 29f is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM.
ENPP1 inhibitor 29f enhances the STING-mediated type I interferon response in HCT116 and THP-1 cells, elevates cGAMP-mediated innate immune response with cancer cell-specific toxicity.
ENPP1 inhibitor 29f significantly enhances STING-mediated type I IFN response of cGAMP and amplifies innate immunity.
ENPP1 inhibitor 29f promotes tumor growth inhibition and enhances the effect of anti-PD-L1 in primary and rechallenged CT26 colorectal tumor model.
ENPP1 inhibitor 29f induces immunological memory prevented the tumor relapse against tumor rechallenge.
| M.Wt | 344.39 | |
| Formula | C16H16N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yeonguk Cho, et al. Journal of Medicinal Chemistry 2023.
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