Chemical Structure : ENPP1 inhibitor 29f
CAS No.:
2738583-25-8
ENPP1 inhibitor 29f
Catalog No.: PC-21326Not For Human Use, Lab Use Only.
ENPP1 inhibitor 29f is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ENPP1 inhibitor 29f is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM.
ENPP1 inhibitor 29f enhances the STING-mediated type I interferon response in HCT116 and THP-1 cells, elevates cGAMP-mediated innate immune response with cancer cell-specific toxicity.
ENPP1 inhibitor 29f significantly enhances STING-mediated type I IFN response of cGAMP and amplifies innate immunity.
ENPP1 inhibitor 29f promotes tumor growth inhibition and enhances the effect of anti-PD-L1 in primary and rechallenged CT26 colorectal tumor model.
ENPP1 inhibitor 29f induces immunological memory prevented the tumor relapse against tumor rechallenge.
Physicochemical Properties
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M.Wt
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344.39
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Formula
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C16H16N4O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-4-((3-Methyl-4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenylsulfamide
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References
1. Yeonguk Cho, et al. Journal of Medicinal Chemistry 2023.
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