ENPP1 inhibitor VIR3

Chemical Structure : ENPP1 inhibitor VIR3

Catalog No.: PC-23567Not For Human Use, Lab Use Only.

VIR3 is a potent, orally bioavailable Enpp1 with IC50 of <0.75 nM for ENPP1 cGAMP hydrolysis activity inhibition in in vitro assays.

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Biological Activity

VIR3 is a potent, orally bioavailable Enpp1 with IC50 of <0.75 nM for ENPP1 cGAMP hydrolysis activity inhibition in in vitro assays.
VIR3 protect spiked-in cGAMP from hydrolysis overnight with an EC50 of 6.7 nM, in cellular assays using HepG2 cells that express ENPP1 on their surface.
VIR3 does not impact tumor growth alone, it significantly improved the response to radiation therapy in Enpp1-negative colorectal carcinoma models.

Physicochemical Properties

M.Wt	386.47
Formula	C19H22N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((R)-2-hydroxypropyl)-4-((7-methoxyquinolin-4-yl)amino)benzenesulfonimidamide

References

1. Baird JR, et al. Sci Rep. 2024 Dec 2;14(1):29913.

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