EP-3945 | MRGPRD agonist | Probechem Biochemicals

Chemical Structure : EP-3945

CAS No.: 3057176-00-5

EP-3945 (EP3945)

Catalog No.: PC-23536Not For Human Use, Lab Use Only.

EP-3945 is a potent, selective Mas-related G protein-coupled receptor MRGPRD agonist with EC50 of 211.6 nM at Gq in BRET assay, inactive against over 300 GPCRs.

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Biological Activity

EP-3945 is a potent, selective Mas-related G protein-coupled receptor MRGPRD agonist with EC50 of 211.6 nM at Gq in BRET assay, inactive against over 300 GPCRs.
EP-3945 activates MRGPRD much more potently than β-alanine and GABA.

Physicochemical Properties

M.Wt	418.50
Formula	C24H26N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1-(1-(4-methoxyphenyl)cyclopropane-1-carbonyl)piperidin-4-yl)amino)quinazolin-4(3H)-one

References

1. Wang C, et al. Cell Rep. 2024 Nov 23;43(12):114942.

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EP-3945 (EP3945)

Biological Activity

Physicochemical Properties

References

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