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Chemical Structure : EP4R antagonist 74
Catalog No.: PC-21514Not For Human Use, Lab Use Only.
EP4R antagonist 74 is a potent, selective EP4 receptor antagonist with Ki of 11.2 nM, shows apparent dissociation constant KB of 16 nM in functional cAMP production-based assays.
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EP4R antagonist 74 is a potent, selective EP4 receptor antagonist with Ki of 11.2 nM, shows apparent dissociation constant KB of 16 nM in functional cAMP production-based assays.
EP4R antagonist 74 shows no binding to EP1, EP2 or EP3 receptors in 3H-PGE2 displacement assays, and no off-target activities against the prostaglandin D2 or thromboxane A2 receptors.
| M.Wt | 368.41 | |
| Formula | C20H21FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gahbauer S, et al. Nat Commun. 2023 Dec 6;14(1):8067.
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