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EP4R antagonist 74

Chemical Structure : EP4R antagonist 74

CAS No.: 2955970-61-1

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EP4R antagonist 74

Catalog No.: PC-21514Not For Human Use, Lab Use Only.

EP4R antagonist 74 is a potent, selective EP4 receptor antagonist with Ki of 11.2 nM, shows apparent dissociation constant KB of 16 nM in functional cAMP production-based assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EP4R antagonist 74 is a potent, selective EP4 receptor antagonist with Ki of 11.2 nM, shows apparent dissociation constant KB of 16 nM in functional cAMP production-based assays.
EP4R antagonist 74 shows no binding to EP1, EP2 or EP3 receptors in 3H-PGE2 displacement assays, and no off-target activities against the prostaglandin D2 or thromboxane A2 receptors.

Physicochemical Properties

M.Wt 368.41
Formula C20H21FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((8-fluoro-9H-pyrimido[4,5-b]indol-4-yl)amino)spiro[3.5]nonane-7-carboxylic acid

References

1. Gahbauer S, et al. Nat Commun. 2023 Dec 6;14(1):8067.

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